Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent.

نویسندگان

  • Y Pu
  • W B Wang
  • G C Tang
  • F Zeng
  • S Achilefu
  • J H Vitenson
  • I Sawczuk
  • S Peters
  • J M Lombardo
  • R R Alfano
چکیده

The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue "optical window". The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.

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عنوان ژورنال:
  • Technology in cancer research & treatment

دوره 4 4  شماره 

صفحات  -

تاریخ انتشار 2005